Luis Garcia Selected Research

Antisense DNA

10/2019	Lowering Mutant Huntingtin Using Tricyclo-DNA Antisense Oligonucleotides As a Therapeutic Approach for Huntington's Disease.
1/2019	Evaluating the Impact of Variable Phosphorothioate Content in Tricyclo-DNA Antisense Oligonucleotides in a Duchenne Muscular Dystrophy Mouse Model.
12/2017	Link between MHC Fiber Type and Restoration of Dystrophin Expression and Key Components of the DAPC by Tricyclo-DNA-Mediated Exon Skipping.
9/2017	Efficacy and Safety Profile of Tricyclo-DNA Antisense Oligonucleotides in Duchenne Muscular Dystrophy Mouse Model.

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Luis Garcia Research Topics

Disease

31	Duchenne Muscular Dystrophy (Muscular Dystrophy, Becker) 01/2022 - 12/2004
14	Muscular Dystrophies (Muscular Dystrophy) 01/2022 - 12/2004
10	Weight Loss (Weight Reduction) 09/2020 - 12/2013
8	Inborn Genetic Diseases (Disease, Hereditary) 01/2019 - 12/2007
4	Morbid Obesity 01/2019 - 12/2013
4	Muscular Diseases (Myopathy) 08/2014 - 05/2009
3	Neuromuscular Diseases (Neuromuscular Disease) 11/2022 - 08/2014
3	Substance-Related Disorders (Drug Abuse) 01/2021 - 01/2016
3	Hypertrophy 07/2019 - 05/2009
3	Feeding and Eating Disorders (Eating Disorder) 09/2017 - 04/2013
3	type 2B Limb-girdle muscular dystrophy 07/2015 - 02/2010
3	Neoplasms (Cancer) 02/2009 - 01/2005
2	Alcoholism (Alcohol Abuse) 01/2019 - 01/2018
2	Binge-Eating Disorder (Binge Eating Disorder) 01/2019 - 01/2019
2	Anxiety Disorders (Anxiety Disorder) 01/2019 - 01/2016
2	Sleep Apnea Syndromes (Sleep Apnea) 01/2019 - 05/2018
2	Cardiomyopathies (Cardiomyopathy) 09/2017 - 03/2015
2	Respiratory Insufficiency (Respiratory Failure) 09/2017 - 03/2015
2	Muscle Weakness 09/2017 - 03/2015
2	Miyoshi myopathy 12/2013 - 02/2010
2	Infections 01/2013 - 11/2005
1	Appendicitis 01/2022
1	Pain (Aches) 01/2022
1	Opioid-Related Disorders (Opiate Addiction) 01/2021
1	Huntington Disease (Huntington's Disease) 10/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2019
1	Cardiovascular Diseases (Cardiovascular Disease) 10/2019
1	Hemorrhage 07/2019
1	Cardiomegaly (Heart Hypertrophy) 07/2019
1	Asthma (Bronchial Asthma) 01/2019
1	Bulimia (Binge Eating) 01/2019
1	Major Depressive Disorder (Major Depressive Disorders) 01/2019
1	Inflammation (Inflammations) 01/2019
1	Metabolic Diseases (Metabolic Disease) 01/2019
1	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 01/2019
1	Apnea 05/2018
1	Sarcopenia 01/2018
1	Wounds and Injuries (Trauma) 01/2018
1	Body-Weight Trajectory 01/2018
1	Critical Illness (Critically Ill) 01/2018
1	Wound Infection (Wound Infections) 01/2018
1	Urinary Tract Infections (Urinary Tract Infection) 01/2018
1	Cognitive Dysfunction 09/2017
1	Deglutition Disorders (Dysphagia) 09/2017
1	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 06/2017
1	Pneumococcal Infections 01/2017
1	Meningitis 11/2016
1	Type 2 Diabetes Mellitus (MODY) 07/2016
1	Hypoglycemia (Reactive Hypoglycemia) 01/2016
1	Mental Disorders (Mental Disorder) 01/2016

Drug/Important Bio-Agent (IBA)

26	DystrophinIBA 01/2022 - 12/2004
14	Proteins (Proteins, Gene)FDA Link 10/2019 - 02/2007
6	OligonucleotidesIBA 10/2019 - 09/2013
5	DNA (Deoxyribonucleic Acid)IBA 03/2020 - 01/2013
5	Messenger RNA (mRNA)IBA 05/2015 - 12/2004
4	Antisense OligonucleotidesIBA 03/2020 - 03/2015
4	Antisense DNAIBA 10/2019 - 09/2017
3	RNA (Ribonucleic Acid)IBA 07/2019 - 06/2011
3	Nonsense Codon (Nonsense Mutation)IBA 09/2017 - 02/2007
3	MyostatinIBA 08/2014 - 05/2009
2	Small Nuclear RNA (snRNA)IBA 06/2020 - 03/2012
2	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 07/2019 - 02/2010
2	C-Reactive ProteinIBA 01/2019 - 10/2012
2	LipidsIBA 01/2019 - 12/2013
2	Glucose (Dextrose)FDA LinkGeneric 07/2016 - 01/2013
2	DysferlinIBA 12/2013 - 02/2010
2	CalciumIBA 07/2013 - 11/2005
2	HDL CholesterolIBA 01/2013 - 10/2012
2	Biological ProductsIBA 05/2008 - 01/2005
1	Palmitic Acid (Hexadecanoic Acid)IBA 11/2022
1	Anti-Bacterial Agents (Antibiotics)IBA 01/2022
1	Naloxone (Narcan)FDA LinkGeneric 01/2021
1	Opioid Analgesics (Opioids)IBA 01/2021
1	polyglutamineIBA 10/2019
1	Vitamin K FDA Link 07/2019
1	Leucine (L-Leucine)FDA Link 07/2019
1	Nitric Oxide Synthase (NO Synthase)IBA 07/2019
1	Protein Isoforms (Isoforms)IBA 07/2019
1	CalcineurinIBA 07/2019
1	GhrelinIBA 01/2019
1	Antidepressive Agents (Antidepressants)IBA 01/2019
1	LeptinIBA 01/2019
1	Biomarkers (Surrogate Marker)IBA 01/2019
1	Cystatin CIBA 01/2019
1	diethylaminosulfur trifluorideIBA 01/2018
1	Conjugate VaccinesIBA 01/2017
1	insulin receptor-related receptor (IRR)IBA 01/2017
1	10-valent pneumococcal conjugate vaccineIBA 01/2017
1	VaccinesIBA 01/2017
1	Combined VaccinesIBA 11/2016

Therapy/Procedure

17	Bariatric Surgery 09/2020 - 10/2012
7	Therapeutics 01/2020 - 01/2005
6	Gastric Bypass (Roux-en-Y Gastric Bypass) 10/2019 - 01/2016
4	Gastrectomy 10/2019 - 02/2009
3	Operative Surgical Procedures 01/2019 - 01/2016
1	Appendectomy 01/2022
1	Length of Stay 01/2018
1	Resuscitation 01/2018
1	Catheters 01/2018
1	Critical Care (Surgical Intensive Care) 01/2018